Allergic patients had higher total serum IgE levels, reported atopic dermatitis and rhinoconjunctivitis more frequently, and, unexpectedly, had a greater disease severity. Nonallergic patients were older at the onset of asthma symptoms and had a higher rate of intolerance to nonsteroidal anti-inflammatory drugs. Results: This study showed different features between asthma phenotypes. Patients' features and HLA class I and II genotypes were assessed and compared. The control group comprised 297 deceased donors of solid organs. They were divided into 2 groups, i.e., allergic and nonallergic asthma, according to their clinical history and skin prick test and serum-specific immunoglobulin E (IgE) results. Methods: A total of 109 patients with asthma were prospectively followed during 2 years. Our objective was to characterize allergic and nonallergic asthma phenotypes and evaluate possible associations with the HLA system. Studies have reported associations between human leukocyte antigens (HLA) and asthma in different populations, but the results have been inconclusive and they have rarely considered the distinct disease phenotypes. Background: Identification of asthma phenotypes enables a better understanding and management of this heterogeneous disease.
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